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diagnosis rheumatology classification management sle allergy comparison differential druginduced erythematosus hypersensitivity reactions systemic vasculitis champs clinicopathology cryoglobulinemia cryoglobulins dil glomerulonephritis
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... Allergen-specific lgE causes ... they activate complement ... glomerulonephritis, Systemic lupus ... #allergy #table
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity Types ... antigen, leading to complement ... Complement activation ... , and systemic lupus ... Diagnosis #Reactions #Table
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
calcium-b) • Laboratory ... 90% - Low complement ... versus DIL • Laboratory ... 80% - Low complement ... sle #comparison #table
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis, type ... 1 (50%-80%), type ... S - Systemic Lupus ... Hypocomplementemia #Low #Complement
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... versus DIL • Laboratory ... Positive in 60-80% of cases ... 80% - Low complement
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Types: • Type ... • Low serum C4 complement ... (e.g. systemic lupus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
and fever) and laboratory ... anti-Smith Ab, low complements ... Kikuchi disease • Type-I ... with: • Minimal laboratory ... RNP antibodies, Complement
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... Epidemiology: -10% of all lupus ... calcium-b) • Laboratory ... 90% - Low complement ... Discontinuation of causal
6/02/2022 UPDATE: This assay is designed to detect non-variola orthopoxviruses, including monkeypox virus. It is not
should use this algorithm ... reference level Laboratory ... The type of specimen ... See table below ... #SmallPox #Laboratory
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