13 results
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm

DIFFUSE
Scarring - Irreversible-biopsy required
 • Lupus
Diagnosis Algorithm ... Irreversible-biopsy required • Lupus ... erythematosus ... • Discoid lupus ... erythematosus
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
- Local and systemic ... antigen, leading to complement ... Complement activation ... , and systemic lupus ... erythematosus
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
antigens, leading to complement ... they activate complement ... chain causing local ... glomerulonephritis, Systemic lupus ... erythematosus Type
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Kikuchi disease • Type-I ... pneumonitis • Diffuse ... enteropathy, and diffuse ... RNP antibodies, Complement
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
glomerulonephritis, type ... 1 (50%-80%), type ... S - Systemic Lupus ... Erythematosus ( ... Hypocomplementemia #Low #Complement
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... Differential Diagnosis Algorithm ... • Systemic Lupus ... Erythematosus ... Hodgkin's Lymphoma #Diffuse
Causes of Hemoptysis - Differential Diagnosis Algorithm
Massive Hemoptysis (>I00 mL in 24 hours)
 • Malignancy
 •
Differential Diagnosis Algorithm ... • Bronchitis Diffuse ... Vasculitis • Lupus ... Erythematosus ... Differential #Diagnosis #Algorithm
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Types: • Type ... • Type III Often ... • Low serum C4 complement ... (e.g. systemic lupus ... erythematosus (
Allopecia - Differential Diagnosis Framework for Hair Loss

Localized / Focal Hair Loss Pattern:
 • Scarring Alopecia:
Localized / Focal ... Disease: Discoid lupus ... erythematosus, ... Traction alopecia Diffuse ... erythematosus,
Focal / Localized Hair Loss (Alopecia) - Differential Diagnosis Algorithm

Scarring - Irreversible-biopsy required
 - Infectious
Focal / Localized ... Differential Diagnosis Algorithm ... • Discoid lupus ... erythematosus ... HairLoss #Alopecia #Focal