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diagnosis allergy classification differential rheumatology pathophysiology reactions glomerulonephritis hypersensitivityreaction immunology nephrology table vasculitis acuteglomerulonephritis allergic asthma bergersdisease c3 c4 causes
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity ... antigen, leading to complement ... Complement activation ... , and systemic lupus ... sclerosis #Hypersensitivity
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
of hypersensitivity ... antigens, leading to complement ... they activate complement ... glomerulonephritis, Systemic lupus ... Graft rejection #hypersensitivity
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
: Summary Type ... conjunctivitis Type ... Graves' Disease Type ... • Ex: Systemic Lupus ... Serum sickness Type
Lupus Nephritis Classification Algorithm #Lupus #Nephritis #Classification #Algorithm #diagnosis #differential #types #rheumatology #nephrology #renal
Lupus Nephritis ... Classification Algorithm ... #Lupus #Nephritis ... Classification #Algorithm ... #differential #types
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
Type III Hypersensitivity ... : • Systemic Lupus ... sickness #TypeIII #Type3
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... C4 ↓↓ • MCGN type ... C3 ↓ C4 ↓↓ • Cryo ... ThePeanutKidney #Complement
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Types: • Type ... • Type III Often ... • Low serum C4 complement ... vasculitis • Hypersensitivity ... (e.g. systemic lupus
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
glomerulonephritis, type ... 1 (50%-80%), type ... S - Systemic Lupus ... Hypocomplementemia #Low #Complement
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
Type II Hypersensitivity ... activates the complement ... cell surfaces #Type2 ... #Type2 #HypersensitivityReaction
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