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diagnosis rheumatology agglutinin anemia c3 clinicopathology cryoglobulinemia cryoglobulins differential erythematosus hematology hemolytic laboratory lupus sle smallpox systemic vasculitis
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Effect of Selected Diseases ... on Complement Levels ... MCGN type 1 C3 ↓ ... C4 ↓↓ • Cryo ... #Levels #C3 #C4
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Disease 3 Types ... Agglutinin Disease ... hemolysis • C3↓ C4 ... temperatures by fixing complement ... Symptoms: High fevers
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... rheumatoid factor level ... • Low serum C4 ... complement level ... #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Classification: ... • Type-I Interferonopathies ... levels (C3 and ... activity • C3 C4
6/02/2022 UPDATE: This assay is designed to detect non-variola orthopoxviruses, including monkeypox virus. It is not
should use this algorithm ... select reference level ... The type of specimen ... depending upon disease ... See table below
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