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diagnosis rheumatology agglutinin anemia c3 c4 clinicopathology cold cryoglobulinemia cryoglobulins disease erythematosus hematology hemolytic laboratory lupus sle smallpox systemic vasculitides
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Levels - C3, C4 ... C4 ↓↓ • MCGN type ... C3 ↓ C4 ↓↓ • Cryo ... #Levels #C3 #C4 ... #differential #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Types: • Type ... rheumatoid factor level ... • Low serum C4 complement ... level • Immunofixation ... #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential ... against MPO • Complement ... (Low levels mixed ... differential #diagnosis ... #rheumatology #classification
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Disease 3 Types ... Cryoglobulins (Vasculitic ... younger pts) Differential ... temperatures by fixing complement ... Symptoms: High fevers
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... permanent alopecia Differential ... Kikuchi disease • Type-I ... levels (C3 and
6/02/2022 UPDATE: This assay is designed to detect non-variola orthopoxviruses, including monkeypox virus. It is not
monkeypox virus or to differentiate ... should use this algorithm ... select reference level ... The type of specimen ... See table below
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