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diagnosis rheumatology differential disease glomerular glomerulonephritis nephrology nephrotic testing workup agglutinin anca anemia cold cryoglobulinemia cryoglobulins ddxof erythematosus gammopathy hematology
A System for Vasculitides #Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... Diagnosis #IM #Rheum #Vasculitis ... #Vessel #Size #Classification ... #Differential #Algorithm
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulins: - Single monoclonal ... - Composed of monoclonal ... • Low serum C4 complement ... • Vasculitis ... diagnosis #types #classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... When to Consider Vasculitis ... SMALL VESSEL VASCULITIS ... against MPO • Complement ... #rheumatology #classification
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... - Idiopathic monoclonal ... malignancy (CLL) - Monoclonal ... Such As: • IgM monoclonal ... temperatures by fixing complement
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
chains - Screen for monoclonal ... for detection of monoclonal ... or alternative complement ... for ANCA-related vasculitis
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
or alternative complement ... chains - Screen for monoclonal ... for detection of monoclonal ... for ANCA-related vasculitis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... ANCA-associated vasculitis ... • Mesenteric vasculitis ... RNP antibodies, Complement
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
aortitis, mimics vasculitis ... - ↑ IgE, ↓ complement ... • Classification
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
Monoclonal Gammopathy ... by nephrotoxic monoclonal ... guide subtype classification ... tubulopathy) - Complement ... formation causing vasculitis
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