Bursitis diagnosis sle pulmonary classification copd management disease hematology syndrome hepatology causes anemia disorders dermatology

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Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage

- Differential Diagnosis ... - Hemolytic anemia ... Associated - SLE ... #hematology #rheumatology ... #nonpalpable #dermatology

Dyspnea - Differential Diagnosis Framework

Cardiovascular Causes of Dyspnea:
• Myocardium:
- Heart failure
- CAD/ACS
- Valvulopathy
• Electrical:
-

- Asthma - COPD ... Hepatopulmonary syndrome ... Transverse myelitis • Hematology ... : - Anemia • ... #causes #pulmonary

Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
• Mechanical Trauma (Microangiopathic hemolytic anemia):

Diagnostic Framework ... Extravascular Causes ... ) - HELLP syndrome ... lymphoproliferative disorders ... #hematology #anemia

Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
• Acute Bleed - Normocytic / Normochromic

- Differential Diagnosis ... Disease • Marrow ... #Classification ... #Algorithm #Causes ... #Hematology

Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
• Enzyme deficiencies ex. G6PD, pyruvate kinase
• Hemoglobinopathies

Differential Diagnosis ... : • Liver disease ... • AIHA: warm, cold ... #causes #classification ... #hematology

Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
- Prior platelet count, family

- Differential Diagnosis ... PT, aPTT(liver disease ... test, ANA (e.g., SLE ... changes), high MCV anemia ... #hematology

Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
•

Causes of Anemia ... - Differential Diagnosis ... • Small Bowel Disorder ... Myelodysplastic Syndromes ... #Hematology

Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
• SLE
• Scleroderma
• Dermatomyositis
Koilonychia - Spoon-shaped

Nail Disorders secondary ... Abnormality • SLE ... Iron deficiency anemia ... Systemic #Secondary #dermatology ... #Algorithm #causes

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Agglutinin Syndrome ... • Symptoms of anemia ... anemia • Cold ... #hemolytic #anemia ... #hematology #diagnosis

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Hemolytic Anemia ... - Differential Diagnosis ... ): SS, SC, SE, Sβ ... Consider RBC membrane disorder ... Algorithm #workup #hematology

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