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management differential antinuclear dermatomyositis lupus syndrome activation antibodies antimda5 antimda5dm antinxp2 antinxp2dm autoantibodies common connectivetissuediseases ctild cvid druginduced erythemas hypogammaglobulinemia
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
interstitial lung ... rheumatoid arthritis SLE ... #Table #Pulmonary ... #Rheumatology # ... Associations
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
with disease activity ... is clinically suspected ... Systemic #lupus #erythematosus ... #diagnosis #rheumatology ... #table #ANA
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... Systemic lupus erythematosus ... , Interstitial Pulmonary ... #patterns #rheumatology ... #diagnosis #differential
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Systemic Lupus Erythematosus ... Evolution: Chronic disease ... #comparison #table ... #rheumatology # ... diagnosis #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... Granulomatous lymphocytic interstitial ... lung disease (GLILD ... Chest CT: • Ground-glass ... hypogammaglobulinemia #immunology #hematology
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
presenting with erythematous ... cancers, including lung ... PrathitKulkarni #Erythemas #comparison ... #table #differential ... #diagnosis #dermatology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
papules Clinical ... severity of the disease ... anti-NXP2 Abs Lung ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
rash) • Heart, lung ... [SLE], AOSD) • ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... Nephrogenic DI Hematologic ... MALT Lymphoma • Lung ... Sjogrens #Syndrome #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
papules Clinical ... had more severe disease ... • Myoglobin Association ... #management #rheumatology ... #dermatology
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