21 results
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Interstitial lung ... , SLEPulmonary ... Vasculitis (e.g. ... #differential # ... diagnosis #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANAAutoimmune ... context of other symptoms ... , Interstitial Pulmonary ... #patterns #rheumatology ... #diagnosis #differential
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... solid cancers • Autoimmune ... diseases: SLE++ ... #management #treatment ... #summary #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
to exclude are infections ... Presentation - Systemic Symptoms ... , and SLE) • Urinalysis ... differential #diagnosis ... #rheumatology #
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... lung disease (GLILD ... Chest CT: • Ground-glass ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Diagnosis: • ANCA-associated ... rheumatologic diseases ... fibromyalgia) • Infections ... Arthritis: • Joint pain ... #Rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
- Arthritis Differential ... Diagnosis Framework ... constitutional symptoms ... Rheumatologic Disease ... rheumatology #Monoarticular
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Vasculitis Differential ... , such as SLE, atherosclerotic ... #Differential #Diagnosis ... #Rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... MALT Lymphoma • Lung ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Clinical Presentation ... pts) Differential ... chills, flank pain ... hemolytic #anemia #hematology