6 results
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANAAutoimmune ... lupus erythematosus ... : Lupus (SLE), Systemic ... , Interstitial Pulmonary ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Diagnosis: • ANCA-associated ... rheumatologic diseases ... antibodies • (-) ANA ... #Diagnosis #Rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
and Systemic lupus ... searched for when ANA ... #Systemic #lupus ... #diagnosis #rheumatology ... #table #ANA
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... diseases: - 10% ... DDX: • ANCA (Antineutrophil ... lupus erythematosus ... classification #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Diagnosis: Systemic ... lupus erythematosus ... SLE) • Urinalysis ... Serologies for Cryoglobulins ... #diagnosis #rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... salivary ducts Clinical ... MALT Lymphoma • Lung ... #Rheumatology #