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ana differential antinxp2dm autoantibodies classification dermatology dermatomyositis igg4 lupus patterns phenotypes related sjogrens syndrome table treatment vasculitides vasculitis workup
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... (SLE), Systemic ... : Lupus (SLE), Systemic ... , Interstitial Pulmonary ... #patterns #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... is clinically suspected ... #lupus #erythematosus ... #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... MALT Lymphoma • Lung ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Clinical history ... female, asian • Systemic ... concentration PET-CT ... #diagnosis #management ... workup #treatment #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammatory lesions-interstitial ... purpura: strong sign ... C-ANCA) pattern: antibodies ... vasculitis, and SLE ... #rheumatology #
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
• Antibodies targeting ... had more severe disease ... • Myoglobin Association ... #diagnosis #management ... #rheumatology #
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