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ana management patterns vasculitis algorithm antibody antineutrophil classification dermatology diseases erythematosus lupus petechiae petechial physicalexam polychondritis rash relapsing syndrome systemic
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... in drug-induced SLE ... • Sjögren syndrome ... #antibodies #diagnosis ... #rheumatology #
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
), Sjogren's Syndrome ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... ), Sjogren's Syndrome ... , Interstitial Pulmonary ... #Antibodies #ANA ... #diagnosis #differential
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... lesions • Severe pain ... Vasculitis (lupus, RA, Sjogren's ... Measurement of antinuclear ... • Abdominal ultrasound
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Diagnosis Framework ... tract, and often causes ... ) pattern: antibodies ... vasculitis, and SLE ... #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... Hypocomplementemia • Can cause ... , INC risk PE, Pulmonary ... #Syndrome #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Diagnosis: • ANCA-associated ... dermatomyositis, Sjogren ... Arthritis: • Joint pain ... #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... tract: Abdominal pain ... tract, and often causes ... involvement, abdominal pain ... #Diagnosis #Rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Sudden onset of pain ... such as: • SLE ... Most common • Sjogren ... Anti-Matrilin-1 Ab ○ Antibodies ... Polychondritis #rheumatology
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