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differential classification patterns vasculitis cryoglobulinemia cryoglobulins disease diseases erythematosus laboratory management rheumatic rheumatoid systemic testing types vasculitides workup
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antibody) and ANCA ... • Sjögren syndrome ... #Antinuclear #Antibody ... #antibodies #diagnosis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers ... ), Sjogren's Syndrome ... , Sjögren Syndrome ... #Antibodies #ANA
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... Juvenile Idiopathic Arthritis ... ), Sjogren's Syndrome ... #Antibodies #ANA ... #patterns #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... : • ANCA-associated ... dermatomyositis, Sjogren ... Joint pain • Swan ... • (-) ANA + (+
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
DDX: • ANCA (Antineutrophil ... cytoplasmic antibody ... (e.g. systemic lupus ... , Sjögren's syndrome ... classification #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... such as systemic lupus ... ) pattern: antibodies ... SLE) • Urinalysis ... #rheumatology #
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
joint • Systemic lupus ... ) - Antinuclear ... antibody (ANA) test ... antibodies, which ... , a negative ANA
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... overlaps with RA, SLE ... Syndrome Diagnosis ... ab • RF • Antinuclear ... #Syndrome #Rheumatology
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