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differential classification management algorithm antineutrophil arthritis cryoglobulins diseases glomerulonephritis laboratory progressive prs renal rheumatic rheumatoid rpgn sjogrens syndrome syndromes testing
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antibody) and ANCA ... Jcortesizaguirr #ANA ... #Antinuclear #Antibody ... #antibodies #diagnosis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers ... : The ANA patterns ... #Antibodies #ANA ... #patterns #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Negative IF): • PR3-ANCA ... (C-ANCA): GPA > ... > eGPA • MPO-ANCA ... (P-ANCA): eGPA,
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
, proteinuria, rapidly ... often causes arthritis ... ) pattern: antibodies ... , and SLE) • Urinalysis ... #rheumatology #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... • Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... cytoplasmic antibody ... #rheumatology #
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... EGPA) • Auto-antibodies ... : ANCA antibody, ... proteinuria • Path: rapidly ... • IF staining patterns
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, proteinuria, Rapidly ... , such as SLE, atherosclerotic ... often causes arthritis ... + MPO) Cryoglobulinemic ... #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
) - Antinuclear ... antibody (ANA) test ... antibodies, which ... Tests for All Types ... (3) Rises more rapidly
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... Hypocomplementemia • Can cause ... : • 7%, Cryoglobulinemia ... Sjogrens #Syndrome #Rheumatology
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