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diagnosis differential rheumatology acidosis cryofibrinogenemia cryoglobulinemia dermatology elevation glomerulonephritis hematology lactate lactic neurology nonpalpable palpable petechiae petechial physicalexam progressive purpura
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
deposit of immune complexes ... • They can cause ... Cause Organ Damage ... • Vasculitis ... diagnosis #types #classification
Causes of Purpura - Differential Diagnosis Non-PalpabIe → Palpable • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... Leukocytoclastic Vasculitis ... (LCV), Immune complex ... mediated (cryoglobulins ... nonpalpable #palpable #Causes
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
precipitation of a complex ... precipitating complex ... cold insoluble complex ... malignancies, vasculitis ... • Negative causes
Causes of Seizures - Differential Diagnosis Algorithm Unprovoked - Epilepsy: • Focal: Simple, Complex • Generalized: Absence,
Causes of Seizures ... Differential Diagnosis Algorithm ... Focal: Simple, Complex ... malformation, Aneurysm, Vasculitis ... #Causes #neurology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Differential Diagnosis Algorithm ... Infection - Vasculitis ... Work Up: • Complete ... immunoglobulins & cryoglobulins
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... immunofluorescence Immune Complex ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... tracts Immune Complex ... tract, and often causes ... Serologies for Cryoglobulins ... #rheumatology #classification
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate ... The most common causes ... / hypoxemia -> focus ... the patient’s complete ... #typea #typeb #classification
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