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diagnosis rheumatology classification differential vasculitis allergy lupus table types arthritis complications cryoglobulinemia cryoglobulins disease genetics hypersensitivity hypersensitivityreaction iem immunology inbornerrors
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... (SLE): Musculoskeletal ... Manifestations • Immune Complex ... #Lupus #Erythematosus ... Complications #pathophysiology
Systemic Lupus Erythematosus (SLE): Pathogenesis • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... (SLE): Pathogenesis ... production of immune complexes ... #Lupus #Erythematosus ... #SLE #Pathophysiology
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
antigen-antibody complexes ... the cause: • Systemic ... Lupus • Erythematosus ... (SLE) If bacterial ... Allergy #Immunology #pathophysiology
A schema of the pathophysiology of the inborn errors of metabolism, excluding complex storage diseases. Helps
schema of the pathophysiology ... metabolism, excluding complex ... connections and pathophysiology ... See the lab values ... #Diagnosis #Algorithm
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... Antigen-antibody complexes ... arthritis, and systemic ... lupus erythematosus ... Classification #Pathophysiology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... deposit of immune complexes ... diseases: - 10% SLE ... lupus erythematosus ... (SLE), rheumatoid
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tracts Immune Complex ... ischemia - Skin: erythematous ... central nervous system ... lupus erythematosus ... vasculitis, and SLE
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
affected joint • Systemic ... lupus erythematosus ... (SLE) - Antinuclear ... 30% and 60% of SLE ... Polyarthritis: • Complete
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis: • Systemic ... diseases, such as SLE ... Presentation: Systemic ... ischemia • Skin: Erythematous ... pauci-immune GN Immune Complex
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