11 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... permeability Diagnosis ... Lumbar Puncture, EEG ... Treatment: ... CNS #neurology #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... . lupus, CLL, lymphoma ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... - Diagnosis and ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... #treatment #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
underlying disease (eg ... • Infection (eg ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... • Malignancy (e.g ... Endocrine disorders (e.g ... #Rheumatology
Congenital Long QT Syndrome: Illness Script

Who?
 - Kids or young adults, usually < 30
 - high
Congenital Long QT Syndrome ... (Torsades) or vFib ... **Get baseline EKG ... family history) Treatment ... #Diagnosis #Cardiology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
organ damage • Treatment ... Low calcium • Treatment ... unless worrisome EKG ... #TLS #diagnosis ... #management #hematology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Labs/Diagnosis: ... tissue disorder (e.g ... . systemic lupus ... Cryoglobulins #diagnosis ... classification #rheumatology
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
any time during treatment ... GBS), systemic lupus ... Atorvastatin Diagnosis ... (SAMS-CI) • EMG ... toxicity #myopathy #diagnosis
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
• A clinical diagnosis ... and lower jaw Treatment ... antiinflammatory properties e.g ... #Rheumatology # ... diagnosis #management