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diagnosis differential abnormal aptt coagulation hepatology pt abscess anemia children dermatology dili druginduced elevatedmcv injury macrocytic macrocytosis management naildisorders peds
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Nonspecific inhibitors e.g ... to one factor e.g ... e.g. heparin ... inhibitory drugs e.g ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
(e.g. heparin contamination ... inhibitory drugs (e.g ... specific inhibitor (e.g ... • Reduced liver ... #differential #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Differential Diagnosis Algorithm ... Increased Requirement (e.g ... • Rule out B12 and ... #Causes #Hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... of information (e.g ... for alternative causes ... vascular disorder (e.g ... #hepatology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
halt nail growth (e.g ... discoloration) • Liver ... Mellitus Half-and-Half ... Differential #Diagnosis #Algorithm ... #causes
Recurrent Polymorphic VT/Torsades de Pointes - Management Algorithm Drugs that prolong QT interval: • Class 1a (quinidine,
Pointes - Management Algorithm ... Drugs that prolong ... • Macrolides and ... 1 gm/hour • Pediatric ... 1b (lidocaine)- case
Pyogenic liver abscess in children Common bacterial causes in children: • S.aureus • Strep spp • Enteric
Pyogenic liver abscess ... Common bacterial causes ... Hepatic artery (e.g ... managed operatively and ... #abscess #pediatrics
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