23 results
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Increased red cell ... Increased red cell ... #Hemolytic #Anemia ... Differential #Causes #Workup ... #Hematology #Diagnosis
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Microangiopathic hemolytic ... Microspherocytes: Autoimmune hemolytic ... red cells: Sickle ... cell disease Bite ... Smear #Analysis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... ) (e.g. lupus, CLL ... Hemoglobinopathies (e.g. sickle cell ... differential #diagnosis #hematology ... #anemia
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... methotrexate) Spurr Cell ... Bite Cell RBC: G6PD ... Target Cell RBC ... differential #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... can indicate disease ... • Neutropenia, anemia ... Leukemia #diagnosis #workup ... #oncology #hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... spherocytosis, Hemolytic ... - Sickle cell anemia ... Schistocytes - Hemolytic ... #differential #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle cells ... Consider sickle cell ... Diagnosis #Algorithm #workup ... #hematology #testing
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoid malignancy (CLL ... malignancies - B-cell ... malignancies -> CLL ... #hemolytic #anemia ... #hematology #diagnosis
Common RBC Inclusions and Associations
 • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia
 • Heinz
Asplenism, Severe hemolytic ... , Hemolytic anemia ... : Hemoglobin H disease ... Thalassemia, Sickle cell ... Bodies #diagnosis #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, CLL Acute leukemias ... extramedullary disease ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis