19 results
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Management Summary ... • Immunologic Workup ... Positive in 60-80% of cases ... Evolution: Chronic disease ... #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Discontinuation of causal ... Evolution: Chronic disease ... #comparison #table ... #rheumatology #
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Workup History ... PT, aPTT(liver disease ... (e.g., SLE), anti-phospholipid ... bypass), LFT (liver disease ... #Workup #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Splenomegaly - CTD ... (SLE) - Viral ... Cryoglobulinemia (MIXED) • ANCA ... Associated - SLE ... #rheumatology #
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
Hypertension - Workup ... signs of end-organ ... renal bruit or signs ... Renal parenchymal disease ... : CKD, acute glomerulonephritis
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Cirrhosis (PBC) - Summary ... intralobular bile ducts causes ... failure PBC Signs ... patients • +ANA ... cholangitis #diagnosis #workup
Kawasaki Disease (KD) - Diagnosis and Management Summary

Kawasaki Disease (KD) is the most common vasculitis of
Kawasaki Disease ... Summary Kawasaki ... Disease (KD) is ... , Cough • +/-Nausea ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Autoimmune diseases ... : SLE+++, Adult-onset ... Still disease, ... management #treatment #summary ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often causes arthritis ... purpura: strong sign ... (Suggest CTD) ... SLE) • Urinalysis ... differential #diagnosis #rheumatology
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
some time, let’s see ... about secondary causes ... you’ll do a good workup ... can drive this disease ... As with many disease