15 results
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Management Summary ... • Immunologic Workup ... : - ANA > ... Evolution: Chronic disease ... #rheumatology
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
Inflammatory Myopathies ... heliotrope, shawl sign ... Pattern: Proximal and ... differential #diagnosis #comparison ... #rheumatology #
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... : - ANA > ... Evolution: Chronic disease ... #comparison #table ... #rheumatology #
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... for All Types of Inflammatory ... inflammatory stimulus ... Arthritis #laboratory #workup ... diagnosis #testing #Rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
noninflammatory Signs ... - Autoimmune Rheumatologic ... arthritis • SLE ... Symmetrical: • RA • SLE ... Diagnosis #MSK #rheumatology
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
), RA, crystal disease ... , crystalline disease ... Chronic = RA, SLE ... Joint #Pain #MSK #rheumatology ... #approach #workup
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
photosensitivity, inflammatory ... Non-autoimmune rheumatologic ... Valvular disorders • CAD ... antibodies • (-) ANA ... Erythematosus #Diagnosis #Rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
(25-75%): Inflammatory ... Oral aphthae : SLE ... • Arthritis: SLE ... diagnosis #management #signs ... #symptoms #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
production of pro-inflammatory ... : SLE+++, Adult-onset ... Still disease, ... management #treatment #summary ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Syndrome: - Ocular inflammatory ... purpura: strong sign ... (Suggest CTD) ... SLE) • Urinalysis ... differential #diagnosis #rheumatology