8 results
ID Approach to Fever and Rash - Diagnostic Algorithm
Central Maculopapular (most common):
Measles, Parvovirus 819 / EBV,
ID Approach to Fever ... Rash - Diagnostic Algorithm ... Parvovirus 819 / EBV, Acute ... Secondary syphilis, EM ... Febrile #Diagnosis #Algorithm
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 ... IFN-y) → Excessive activation ... accumulation of clinical ... Assessment • Clinical ... : fever +++, hepatosplenomegaly
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... syndromes Clinical ... is the main clinical ... 5000 to 10,000 ng/mL ... MAS #Macrophage #Activation
Acute Dacryocystitis- A 4-week-old boy was brought to the emergency department after having drainage from both
Acute Dacryocystitis ... - A 4-week-old boy ... eyes, and a 1-cm ... agents, and the fever ... #NEJM #clinical
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... excessive macrophage activation ... presents as an acute ... following: • Fever ... Ferritin >500 ng/mL
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework

Viral Encephalitis:
MCC: Enteroviruses (e.g., coxsackievirus
Powassan, louping ill ... • Headache • Fever ... • Common clinical ... Symptoms: • Acute ... meningeal signs (fever
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... weight loss, and fever ... Classification: • Acute ... to: Arthritis, Fever ... Chronic B-cell activation
SEPSIS AND SEPTIC SHOCK

DEFINITION AND PATHOPHYSIOLOGY
 • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
cytokines, complement activation ... CLINICAL RECOGNITION ... in any acutely ill ... • Symptoms: Fever ... CLINICAL FEATURES