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diagnosis differential hematology activation agglutinin algorithm anemia autoimmune behcet causes hemolytic hypoxemia hypoxia leukemia macrophage mas monoclonal multiple myopathy myositis
Multiple Cranial Neuropathies - High Yield Differential Diagnosis • Intrinsic brainstem process • Compressive brainstem process
Multiple Cranial ... Neurosarcoidosis • CNS ... Lyme Disease, TB ... Miller Fisher Syndrome ... variant-GBS • Bulbar ALS
Hypoxemia / Hypoxia - Rapid Response Management Algorithm Stridor - Upper airway pathology: • Anaphylaxis • Foreign
Rapid Response Management ... asthma • Pleural disease ... Hypoventilation: • CNS ... e.g., GBS, MG, ALS ... differential #Diagnosis #Management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... involvement • 30%: CNS ... : CNS manifestations ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... • Heavy Chain disease ... Scleromyxedema (CNS ... anemia due to cold ... Differential #Diagnosis #Oncology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
basal ganglia, CNS ... meningitis), MCC CNS ... collaboration • CNS ... #diagnosis #management ... signs #symptoms #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Disease 3 Types ... Agglutinin Syndrome ... (CAS): - Due ... hemolysis • C3↓ C4 ... hemolytic #anemia #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Parotid swelling CNS ... nervous system (CNS ... , myelopathy, cranial ... • 8%-27% for CNS ... #Rheumatology #
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... nervous system (CNS ... tests ↑ AST ↑ ALT ... #Diagnosis #Management ... #Hematology #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... Antisynthetase syndrome ... Polymyositis or ALS ... nucleotidase 1A (Anti cN ... Myositis #Myopathy #rheumatology
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