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diagnosis differential neurology gravis algorithm bee cns demyelinating flaccid floppy hearing hypotonic infant lmn loss musclearc muscleweakness myelitis neuromuscular neuromuscularjunctions
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Demyelinating Disease ... (MS), Epidural ... heavy metals), Critical ... , Myasthenia Gravis
Causes of Hypotonic Infant (Floppy Newborn) - Differential Diagnosis Algorithm Central Nervous System - Decreased LOC, Axial
Hemorrhage • CNS ... Other Congenital Syndromes ... Spinal Muscular Atrophy ... Peripheral Weakness - Nerves ... and Transient Myasthenia
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Clinical Picture ... Brain stem/Cranial nerve ... - Repetitive nerve ... immunologic assay - MuSK ... Gravis #diagnosis #management
Myasthenia Gravis - Summary • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Diagnosis: • Based on clinical ... antibodies - MuSK-positive ... likely to cause ... - Improves clinical ... Gravis #diagnosis #management
BEE Syndromes - Non-inflammatory Causes Immune-mediated conditions affecting the Brain, Eye, and Ear Visual or auditory symptoms in
Non-inflammatory Causes ... nervous system (CNS ... (WFS1), optic atrophy ... MRI lesions and clinical ... consistent with MS
Ptosis - Differential Diagnosis Framework Ptosis (Greek- to fall) Drooping of the upper eyelid that usually results
think about three clinical ... CN III palsy 2. ... Ptosis - Neurologic disease ... junction, cranial nerve ... eyelid: • Third nerve
Hearing Loss - Differential Diagnosis Framework Hearing Loss Types: • Conductive • Sensorineural • Mixed Presbycusis is the most common type
(CN 8) ... Onset ○ Meniere disease ... II ○ Susac’s syndrome ... Noise trauma ○ MS ... ○ HIV ○ Lyme disease
Upper Motor Neuron (UMN) lesions are lesions occurring anywhere in the CNS from the brain up
anywhere in the CNS ... may arise from disease ... LMN syndromes are ... acetylcholine (Ach ... cord, peripheral nerve
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Parotid swelling CNS ... nervous system (CNS ... myelopathy, cranial nerve ... • 8%-27% for CNS ... phenomenon (16%) MSK
DEMYELINATING DISEASES OF THE CENTRAL NERVOUS SYSTEM What Are Demyelinating Diseases? • Conditions that damage myelin, the protective
nervous system (CNS ... • Clinical Types ... - Symptom management ... autoimmune/infectious causes ... #neurology #CNS
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