33 results
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
• Transverse myelitis ... pain • Extra-CNS ... positive NMO only): Myositis ... Manifestations #diagnosis
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
- Differential Diagnosis ... pulmonary etc) • CNS ... -> PNS -> NMJ - ... cryoglobulins • PNS ... #Differential #Diagnosis
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Myositis Specific ... Inclusion Body Myositis ... MithuRheum #Myositis ... MSAs #clinical #diagnosis ... #rheumatology #table
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis ... that results in CNS ... bouts of HTN Diagnostic ... Diagnosis: • ... #diagnosis #management
Lung Auscultation and Physical Exam Findings in Selected Lung Disorders

#PhysicalExam #Auscultation #Pulmonary #Percussion #Dullness #Fremitus #BreathSounds
Lung Disorders #PhysicalExam ... Transmitted #Comparison #Table ... #Lung #Diagnosis
Causes of Relative Bradycardia - Note the propensity for intracellular organisms.
Infectious: 
Legionella, Psittacosis, Q fever, Typhoid
: ß-blockers, CNS ... #differential #diagnosis ... infectiousdiseases #table
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
Associated Features: Diagnosis ... Inclusion Body Myositis ... over years, often diagnosed ... #differential #diagnosis ... #rheumatology #table
Nail diseases and disorders.
 - Spoon Nails (Koilonychia)
 - Pitting of Nails
 - Beau's Lines
 -
white spots) #Diagnosis ... #Leukonychia #Table ... #Clinical #PhysicalExam
Hyponatremia - Differential Diagnosis by Mechanism
Decr Blood Pressure (“Decr Effective Circulating Volume”) 
 - Volume depletion
- Differential Diagnosis ... the lung) - CNS ... #Differential #Diagnosis ... #Table #Causes
Cholecystitis Diagnostic Test Characteristics  

Sensitivity, Specificity and Likelihood Ratios of Labs, Physical Exam findings, and
Cholecystitis Diagnostic ... Cholecystitis #Diagnosis ... Characteristics #Table ... LikelihoodRatio #Accuracy #PhysicalExam