11 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoproliferative disorder ... Agglutinin Syndrome ... (CAS): - Due ... younger pts) Differential ... hemolytic #anemia #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... anemia due to cold ... Sneddon-Wilkinson disease ... #Monoclonal #Differential ... #Diagnosis #Oncology
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Nail Disorders secondary ... Nail Fold Abnormality ... Muehrcke's Lines - Transverse ... • Nephrotic syndrome ... #dermatology #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Autoimmune (AIHA)"Cold ... (e.g. primary cold ... lymphoproliferative disorders ... Extravascular #Causes #differential
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... super-antigen mediated disease ... Pallidum - Lyme Disease ... MCTD - Bechet disease ... management #neurology #differential
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
Spinal Cord Disorders ... - Differential ... sclerosis - Transverse ... Sarcoidosis, Behcet disease ... MCTD, Sjogren syndrome
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... ) • Endocrine disorders ... and CNS • Headache ... dysfunction, and mood disorder ... neuropathy • Transverse
Upper Motor Neuron (UMN) lesions are lesions occurring anywhere in the CNS from the brain up
anywhere in the CNS ... may arise from disease ... may mimic an LMN disorder ... form part of the differential ... LMN syndromes are
Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation: 
1. Acidemia or Alkalemia? 
2.
Acid Base Disorders ... D-lactate (short bowel syndrome ... acidosis: - CNS ... restrictive lung disease ... (COPD, OSA, Asthma
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... Myeloproliferative Disease ... Neutropenia • Platelet Disorders ... blood count with differential ... #oncology