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rheumatology neurology cauda caudaequina causes equina erythematosus gitelman hypokalemia immune inflammatory iris lupus myelitis nephrology pathophysiology reconstitution sjogrens sle systemic
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Diagnosis: • Dry ... myelopathy, cranial nerve ... peripheral neuropathy, transverse ... • 8%-27% for CNS ... #Management
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... Pleocytosis > 100 cells ... brain and/or optic nerve ... #management #neurology ... #differential
Cauda Equina Syndrome Overview Cauda Equina Syndrome: • Prevalence: 1:33,000-100,000 ppl/yr • Incidence: 1.5-3.4 million ppl/yr •
compression of nerve ... (CES) is usually ... Diagnosis: • ... myelopathy • Transverse ... #differential #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Diagnosis: • ANCA-associated ... and CNS • Headache ... neuropathy • Transverse ... Erythematosus #Diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Diagnosis Framework ... Multinucleated giant cells ... muscle weakness • Nerves ... chorioretinitis, CNS
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... pleural effusions, CNS ... #Inflammatory #Syndrome ... #Differential # ... Diagnosis #Management
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
apical membrane of cells ... Hypocalciuria (spot ... ratio 0.5%) Differential ... #diagnosis #nephrology ... #management #pathophysiology
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