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diagnosis differential rheumatology management dermatology oncology activation agglutinin algorithm anemia arterial bariatric behcet bypass causes classification coagulation cold complications dic
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Primary: 50% Cutaneous ... : CTD: SLE, RA related ... : • Behcet Disease ... • Cogan syndrome ... #dermatology #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Splenomegaly - CTD ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... EGPA - MPA • CTD ... Differential #Diagnosis #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: • Behçet Syndrome ... aphthous ulcers, cutaneous ... • Cogan Syndrome ... strong sign of cutaneous ... • ANA (Suggest CTD
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Rheumatologic, Vasculitides ... , IBD, Celiac disease ... Diagnosis #Algorithm #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
, small-vessel vasculitis ... panuveitis, retinal vasculitis ... ) • Cutaneous Lesions ... Arthritis, AS Treatment ... signs #symptoms #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... gangrenosum • Cutaneous ... Autoimmunity: • -MM/WM: Vasculitis ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Strong sign of cutaneous ... (lower legs), cutaneous ... • Behcet syndrome ... aphthous ulcers, cutaneous ... • Cogan syndrome
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Cold Agglutinin Syndrome ... (CAS): - Due ... presentation) • Cutaneous ... hemolytic #anemia #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
scarring • Subacute cutaneous ... ANCA-associated vasculitis ... Malignancy (e.g. hematologic ... involve PNS and CNS ... Vasculitis: •
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
skin (xerosis) • Cutaneous ... vasculitis: 10% ... Nephrogenic DI Hematologic ... : 2% Systemic Vasculitis ... Adenocarcinoma Treatment
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