21 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Malignancy (e.g. hematologic ... CNS • Headache ... vein thrombosis Hematologic ... antibodies • (-) ANA ... : • Chronic B-cell
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Systemic lupus erythematosus ... nervous system (CNS ... Triglycerides • ↑ Lactate ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
cells can indicate disease ... and other C Cell ... microglobulin Treatment ... diagnosis #workup #oncology ... #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... Demyelinating Syndrome ... Cerebrovascular Disease ... Puncture, EEG Treatment ... #rheumatology #
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... lymphoid malignancy (CLL ... Hyperbilirubinemia • Elevated lactate ... malignancies -> CLL ... hemolytic #anemia #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
commonly through its ... purpuric macules • Erythematous ... • Ulcerated, erythematous ... • Goodpasture syndrome ... • Giant cell arteritis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Lymphoma (HCV) • CLL ... • Heavy Chain disease ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Lymphocytic Leukemia (CLL ... chemotherapy for low-risk disease ... lymphadenopathy and ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
urine, sweat) - its ... disease states ... the critically ill ... regional ischemia, surgery ... - Compartment syndrome