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Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... pulmonary disease, and ocular ... ulcers, cutaneous, ocular ... Syndrome: - Ocular ... purpura: strong sign
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
purpura: Strong sign ... tract, and often causes ... pulmonary disease, and ocular ... ulcers, cutaneous, ocular ... Cogan syndrome: Ocular
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
ulceration • Ocular ... skin injury) • Neurologic ... spondyloarthritis • Ocular ... Leukemia, Lymphoma Ocular ... #symptoms #rheumatology
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
hypertension and signs ... renal bruit or signs ... Causes: • Vascular ... Coarctation of aorta, Vasculitis ... Neurologic disorders
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
desaturation, Scotoma, Ocular ... involvement: Intractable nausea ... Comorbid autoimmune disorders ... Manifestations #diagnosis #neurology ... #symptoms #signs
Photophobia and Headache - Differential Diagnosis Framework

Why?
• The coexistence of photophobia and headache suggests the potential
meningeal irritation signs ... glaucoma - Ocular ... inflammatory disorder ... headache • CNS Vasculitis ... ophthalmology #Neurology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
malignancies, vasculitis ... cryoglobulinemia Associated Disorders ... pulmonary emboli, and ocular ... cryoglobulins • Negative causes ... Cryofibrinogenemia #diagnosis #rheumatology
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
an autoimmune disorder ... Ocular- 50%: Ptosis ... test - Cogan sign ... - Peek sign ... diagnosis #management #neurology