9 results
Microorganisms Responsible for Infective Endocarditis

Native valves:
 - Streptococcus viridans 
 - Enterococci 
 - Other streptococci
Responsible for Infective ... (Candida, Aspergillus ... Histoplasma) - Culture ... negative #Infective ... Pathogens #Diagnosis #Differential
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
Causes of blood ... infective endocarditis ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... #differential #
Causes of Culture Negative Abscess - Differential Diagnosis Framework
Consider prior antibiotics as a cause of a
Causes of Culture ... Negative Abscess ... - Differential ... antibiotics as a cause ... Scedosporium, endemic fungi
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
fastidious bacteria or fungi ... but important causes ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... Endocarditis #diagnosis #differential
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan
Beta-D-Glucan:
 • Polysaccharide cell wall component of many fungi
 • Pathogens:
component of many fungi ... • Pathogens: Candida ... invasive fungal infection ... BAL GM does not differentiate ... Galactomannan #diagnosis #comparison
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Hypercoagulable (APLAS ... Tropheryma Whipplei • Aspergillus ... Septic Emboli Cause ... Marantic (NTBE) Differential ... Treat underlying cause
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm
Structural Defect - Asplenia/HypospIenism
 • Bacteremia/Septic
Causes of Fever ... Immunocompromised Host - Differential ... Pneumonia • Aspergillus ... • Candida • ... • Abscess Formation
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
- Overview and Differential ... Hypercoagulable (APLAS ... Tropheryma Whipplei • Aspergillus ... Septic emboli cause ... #Endocarditis #Differential
Majocchi’s Granuloma due to Trichophyton rubrum 
This is GMS stain and culture of a skin biopsy
tissues - mainly caused ... Non-dermatophytes: Aspergillus ... plaques, pustules, abscess ... Fungal infection ... clinical #photo #microscopy