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diagnosis fungal microbiology morphology pathology endocarditis infections infectiousdiseases bcnie betadglucan galactomannan infective negative table yeasts bacteria biomarkers bloodculture cardiology causes
Microorganisms Responsible for Infective Endocarditis Native valves: - Streptococcus viridans - Enterococci - Other streptococci
Gram-negative bacilli - Fungi ... (Candida, Aspergillus ... Histoplasma) - Culture ... streptococci - Culture ... Pathogens #Diagnosis #Differential
Morphology and Descriptions of Fungal Infections with Hyphae or Pseudohyphae in Tissues Yeasts with Pseudohyphae: •
Consistent with Candida ... spp. however Aspergillus ... other hyaline fungi ... #microbiology #differential ... septations #pathology #atlas
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
Causes of blood culture ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... BCNIE #Causes #differential ... diagnosis #causes #culture
Morphology and Descriptions of Endemic Fungal Infections with Yeasts in Tissues Broad-based budding yeasts: • Description: Broad-based
other hyaline fungi ... with dematiaceous fungi ... yeasts #fungal #fungi ... #microbiology #differential ... morphology #pathology #atlas
Morphology and Descriptions of Endemic Fungal Infections with Yeasts in Tissues Broad-based budding yeasts: • Description: Broad-based
Coccidioides spp, Candida ... Cryptococcus, and Aspergillus ... yeasts #pathology #clinical ... #atlas #fungi # ... microbiology #differential
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
fastidious bacteria or fungi ... antimicrobials, clinical ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... Endocarditis #diagnosis #differential
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
preparation from culture ... cell response to fungi ... exceptions are Aspergillus ... #microbiology #microscopy ... #fungus #comparison
Common Fungal Pathology • Candida - Small yeast intermingled with pseudohyphae • Aspergillosis - Septate
Pathology • Candida ... Fungal #Pathology #clinical ... #microscopy #table ... #atlas #key #comparison
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
component of many fungi ... • Pathogens: Candida ... cut-offs defined in clinical ... BAL GM does not differentiate ... Galactomannan #diagnosis #comparison
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
component of many fungi ... • Routine use: Candida ... >90% (In most clinical ... in BAL does not differentiate ... closely related fungi
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