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diagnosis differential infectiousdiseases infective cardiology negative table bcnie clinical fungal management microbiology algorithm bacteria bloodculture bloodcultures cnie fungi fungus granuloma
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
Causes of blood ... infective endocarditis ... whipplei, Fungi (Aspergillus ... , Candida), Mycoplasma ... #Endocarditis #
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures - Did they receive antibiotics prior
with Infective Endocarditis ... therapy - Number one cause ... Fungal (Histoplasma/Aspergillus ... patient a surgical candidate ... #Infective #Endocarditis
Microorganisms Responsible for Infective Endocarditis Native valves: - Streptococcus viridans - Enterococci - Other streptococci
for Infective Endocarditis ... bacilli - Fungi (Candida ... , Aspergillus, Histoplasma ... ) - Culture negative ... streptococci - Culture
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Hypercoagulable (APLAS ... Culture (+): ... Tropheryma Whipplei • Aspergillus ... Septic Emboli Cause ... Treat underlying cause
Common Fungal Pathology • Candida - Small yeast intermingled with pseudohyphae • Aspergillosis - Septate
Pathology • Candida ... Pathology #clinical #microscopy ... #table #atlas # ... key #comparison
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Infective Endocarditis ... but important causes ... whipplei, Fungi (Aspergillus ... , Candida), Mycoplasma ... Negative #Infective #Endocarditis
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
from Infective Endocarditis ... negative blood cultures ... Negative blood cultures ... in up to 30% of cases ... #comparison #infective
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Endocarditis - Overview ... Hypercoagulable (APLAS ... Tropheryma Whipplei • Aspergillus ... Septic emboli cause ... Treat underlying cause
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
preparation from culture ... exceptions are Aspergillus ... #microbiology #microscopy ... fungi #fungus #comparison
Majocchi’s Granuloma due to Trichophyton rubrum This is GMS stain and culture of a skin biopsy
GMS stain and culture ... Culture: Trichophyton ... tissues - mainly caused ... Non-dermatophytes: Aspergillus ... clinical #photo #microscopy
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