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diagnosis endocarditis infectiousdiseases causes infective betadglucan bloodculture cnie falsepositives fungal galactomannan incidence infections laboratory management microbiology myocarditis pathogens sensitivity testing
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... , these bacteria ... #Causes #differential ... #BCNIE #cardiology
Microorganisms Responsible for Infective Endocarditis Native valves: - Streptococcus viridans - Enterococci - Other streptococci
bacilli - Fungi ... (Candida, Aspergillus ... bacilli - Fungi ... #Endocarditis #Bacteria ... Pathogens #Diagnosis #Differential
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... remain negative ... or fungi (grows ... (Aspergillus, Candida ... Endocarditis #diagnosis #differential
Transplant Infections Timeline Pre-transplant: • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut) • Viruses: HSV (reactivation) Engraftment:
Staphylococci (skin), Gram-negative ... : Candida spp. ... (mucosa), Aspergillus ... : Aspergillus spp ... Infections #Timeline #differential
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
component of many fungi ... • Routine use: Candida ... Almost always negative ... Infections with certain bacteria ... in BAL does not differentiate
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
• Coagulase-negative ... Tropheryma Whipplei • Aspergillus ... Marantic (NTBE) Differential ... • Persistent bacteremia ... diagnosis #management #cardiology
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
- Overview and Differential ... Negative: • Bartonella ... Tropheryma Whipplei • Aspergillus ... • Persistent bacteremia ... #Diagnosis #cardiology
Causes of Myocarditis 1. Infectious Myocarditis • Bacterial - Staphylococcus, Streptococcus, Pneumococcus, Meningococcus, Gonococcus, Salmonella, Corynebacterium
Myocarditis • Bacterial ... ) • Fungal - Aspergillus ... , Blastomyces, Candida ... Myocarditis #Causes #differential ... #diagnosis #cardiology
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