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diagnosis disease adultonset aosd syndrome activation adult calcium comparison cppd deposition differential druginduced hemophagocytic hlh immune inflammatory iris lupus lymphohistiocytosis
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... solid cancers • Systemic ... #AdultOnset #Stills ... Disease #diagnosis #management ... #treatment #rheumatology
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... episode (30%) Systemic ... Disease #AOSD #rheumatology ... #diagnosis #management ... #treatment
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... Disease Systemic ... Treatment - Mild ... AOSD #diagnosis #rheumatology ... #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
sJIA) • Adult-onset ... Still disease ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
SLE+++, Adult-onset ... Still disease, ... Lymphohistiocytosis #diagnosis #management ... #treatment #summary ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... months to years) Systemic ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Acute Recurrent Pericarditis = recurrence of Acute Pericarditis (AP) after free interval >4-6 weeks without symptoms, >1/4
Subacute ≠ acute onset ... Myopericarditis, Systemic ... Pericarditis #diagnosis #management ... #treatment #rheumatology ... #cardiology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
reconstituted immune system ... initiation and onset ... Fever, chills, lack ... meningitis • Guidelines ... Differential #Diagnosis #Management
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
characterized by sudden onset ... Acute Pseudogout: Treatment ... polyarticular CPPD • Systemic ... Deposition #Disease #Rheumatology ... #diagnosis #management
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