28 results
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
overgrowth: • Carpal ... Tunnel Syndrome ... Overproduction #diagnosis ... #signs #symptoms ... #endocrinology
Acromegaly 
Caused by over-secretion of growth hormone (GH) from the pituitary gland. 
The condition is rare
Acromegaly Caused ... #Acromegaly #Signs ... #Symptoms #Diagnosis ... #Endocrinology
Multiple Endocrine Neoplasias (MEN syndromes) 

MEN I
• Hyperparathyroidism 
• Hypercalcemia 
• Possible ZE syndrome 
• Various
Neoplasias (MEN syndromes ... • Possible ZE syndrome ... Pituitary path • Acromegaly ... #Differential #Endocrinology ... Classification #Diagnosis
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... - Giantism or acromegaly ... expansion (e.g. carpal ... #FeedbackLoop #endocrinology
Hirsutism - Differential Diagnosis
Defined as excessive dark, coarse, male-pattern hair growth
Hirsutism causes in premenopausal women:
 •
- Differential Diagnosis ... Rare: Cushing's Syndrome ... , Acromegaly • ... #Differential #Diagnosis ... #endocrinology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Acromegaly - Diagnosis ... paresthesias (carpal ... decade → peripheral/acral ... Beckwith Wiedemann syndrome ... #Endocrinology
Triquetral Fracture
The triquetrum is the second most commonly fractured carpal bone. Look for the "pooping duck
"pooping duck sign ... "pooping duck sign ... Discharge with orthopedic ... Radiology #XRay #Diagnosis ... #Management #Orthopedics
Ramsay Hunt Syndrome - Herpes Zoster Oticus 
Triad:
1. Ipsilateral facial paralysis 
2. Ear pain 
3. Vesicles
Ramsay Hunt Syndrome ... in the auditory canal ... • Stroke syndromes ... HerpesZoster #Oticus #Diagnosis ... #Symptoms #Signs
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
– symptoms and signs ... peripheries, Carpal ... timel syndrome, ... #Symptoms #Diagnosis ... #PhysicalExam #Endocrinology
Scapholunate Dissociation
The spacing between all carpal bones should be 1-2 mm, look for the "Terry Thomas"
"Terry Thomas" sign ... to diagnosis scapholunate ... ("Terry Thomas sign ... follow-up with orthopedics ... #Management #Orthopedics