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diagnosis growthhormone acromegaly excess feedbackloop keratoconus management overproduction pituitary symptoms treatment
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
overgrowth: • Carpal ... Tunnel Syndrome ... Overproduction #diagnosis #signs ... #symptoms #endocrinology ... #pathophysiology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... expansion (e.g. carpal ... tunnel, OSA, Incr ... #FeedbackLoop #endocrinology ... #pathophysiology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
paresthesias (carpal ... tunnel) and OSA ... malignancy Pathophysiology ... Beckwith Wiedemann syndrome ... Diagnosis #Management #Endocrinology
Keratoconus: Pathogenesis and Clinical Findings Genetics • Family history of keratoconus • Ehlers-Danlos syndrome • Down, Turner,
Ehlers-Danlos syndrome ... • Down, Turner ... , Marfan syndromes ... #Keratoconus #pathophysiology ... #ophthalmology
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