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diagnosis gh growthhormone acromegaly feedbackloop management overproduction pituitary symptoms treatment
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
overgrowth: • Carpal ... Tunnel Syndrome ... Overproduction #diagnosis #signs ... #symptoms #endocrinology ... #pathophysiology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... lipid • GH excess ... expansion (e.g. carpal ... tunnel, OSA, Incr ... #pathophysiology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
paresthesias (carpal ... tunnel) and OSA ... - If GH excess ... Beckwith Wiedemann syndrome ... Diagnosis #Management #Endocrinology
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