11 results
Characteristic clinical manifestations of Down syndrome 
 
Typical craniofacial appearance 
 • Round face and flat
Brushfield spots in iris ... susceptibility to infections ... impairment from cataracts ... #Downs #Syndrome ... #PhysicalExam #
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
desaturation, Scotoma, Ocular ... (AQP4-lgG disease ... complications (AQP4-positive ... Manifestations #diagnosis #neurology ... #symptoms #signs
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... worsening of that disease ... skin lesions, ocular ... Zoster flare, ocular ... #Inflammatory #Syndrome
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
IRIS might ... status, and focal neurologic ... Demyelinating disease ... and <25% culture positive ... patients with IRIS
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
ulceration • Ocular ... skin injury) • Neurologic ... meningitis), MCC CNS symptoms ... Skin lesions • Positive ... management #signs #symptoms
Neurological Manifestations of Tuberculosis
Spinal Arachnoiditis & Polyradiculopathy:
 • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
lesion Pott's Disease ... Reconstitution Inflammatory Syndrome ... (IRIS): • In HIV ... and not direct infection ... differential #TB #neurology
The Stages of Syphilis 

Primary Syphilis 
- The chancre lesion is the hallmark of primary syphilis.
- Ocular syphilis ... and nephrotic syndrome ... exposure to or symptoms ... serology but do ... Diseases - https
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
to exclude are infections ... Presentation: Systemic Symptoms ... affects the skin, neurologic ... • Progressive symptoms ... cognitive impairment, neurologic
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Statins - ETOH - Infection ... : • Triad of symptoms ... urine • Other symptoms ... Myoglobinuria: UA positive ... of underlying disease
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
extrapulmonary disease ... or meningitic disease ... by culture or serology ... osteoarticular, pulmonary, ocular ... have positive blood