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C. Difficile Infection in IBD - IBD Algorithm

Background
Complications
CDI Testing Algorithm
CDI Recurrence

Dr. Wade Billings @wabillin

#Clostridioides #difficile #CDiff
- IBD Algorithm ... Complications CDI ... Testing Algorithm ... CDI Recurrence ... Clostridioides #difficile #CDiff
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook

Clinical Presentation + Progression:
C.diff - Clostridioides ... Epidemiology: • #1 ... immunocompromised, IBD ... 10 mg/kg IV x 1 ... #Cdiff #Clostridioides
Relapsing Acute Severe Ulcerative Colitis - Management Algorithm
Loss of Response:
 • (Re)consult Colorectal Surgery
 • Assess
Diff. & CMV COVID ... surgery: Fulminant UC ... Optimize Nutrition • CNI ... Ulcerative #Colitis #UC ... #IBD #Treatment
Fatigue and IBD Algorithm
 • 40-50% patients have fatigue despite clinical remission
 • Risk factors: BMI,
Algorithm • 40- ... Prevalence Crohn's > UC ... disease control • 1/ ... modifications Algorithm ... #Algorithm #diagnosis
Perioperative IBD Pharmacotherapy Management 
Immunomodulators:
 • Stop MTX one week prior to elective surgery
 • Stop
Perioperative IBD ... resume post op day 1 ... • Resume in CD ... Discontinue in UC ... Perioperative #IBD
Orofacial Granulomatosis - Diagnosis and Management Algorithm
Idiopathic OFG: isolated swelling of the lips, BX+ non-caseating granuloma
Melkersson-Rosenthal
and Management Algorithm ... oral manif. of IBD ... ; UC>CD • Snail ... Resolve w Rx of IBD ... Algorithm by Dr
A proposed management algorithm for CDI in patients with inflammatory bowel disease. *Severe-complicated CDI is defined
proposed management algorithm ... for CDI in patients ... Severe-complicated CDI ... #CDI #CDiff #clostridiumdifficile ... #IBD #Algorithm
Ulcerative Proctitis
Proctitis:
 • Affects 1/3 patients
 • Predictors of extension:
     - Disease
Proctitis: • Affects 1/ ... Infection (CMV, c-Diff ... rectal prolapse, CD ... Ulcerative #Proctitis #IBD ... diagnosis #management #algorithm
Diets and Inflammatory Bowel Disease (IBD)
Diet affects IBD by 3 mechanisms
1. Microbiome ( ↓ diversity)
2. Mucosal
Bowel Disease (IBD ... Diet affects IBD ... 3 mechanisms 1. ... of diet therapy CD ... > UC • Patient
Thiopurines in IBD
Indications:
 • Steroid-sparing agents indicated for maintenance of remission in UC and CD
 •
Thiopurines in IBD ... of remission in UC ... and CD • Not ... -3mg/kg and MP 1- ... Monitor CBC q 1-