21 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
of Clinical Significance ... - Differential Diagnosis ... nemaline myopathy Cutaneous-centered ... #Gammopathy #Clinical ... #hematology #oncology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... - Purpura - Skin ... Syndrome: • Clinical ... Henoch-Schönlein purpura) • Cutaneous ... classification #rheumatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral Infection Clinical ... presentation) • Cutaneous ... Monoclonal IgM ... hemolytic #anemia #hematology ... #diagnosis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Alpha & Mu) Skin ... gangrenosum • Cutaneous ... thrombosis+Pulm HTN+skin ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... Differential Diagnosis ... #rash #diagnosis ... #rheumatology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
arterial thrombosis, skin ... : • Clinical Suspicion ... exposure (prevent skin ... Can consider re-challenge ... Management #Treatment #Hematology
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
DERMATOMYOSITIS Cutaneous ... ulcerations • Skin ... auricular papules Clinical ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
association • M > F Clinical ... vasculitis) • Cutaneous ... Behcet syndrome (Clinical ... refractory disease : monoclonal ... signs #symptoms #rheumatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Cryofibrinogenemia Clinical ... : • + Clinical ... cryoglobulins • Negative causes ... #rheumatology # ... hematology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rheumatic pain Clinical ... : • A clinical ... out other causes ... SAPHO #Syndrome #Rheumatology ... #Dermatology