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diagnosis hematology oncology causes cll lymphocytic management aids algorithm basophilia basophils fungal hemeonc hiv immunecompromised immunodeficiency lung mds mycobacteria mycoses
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Host - Differential ... Neutropenia or ... Bronchitis • Chronic ... #Fever #Immunocompromised
Infections in Immunocompromised Patients - Differential Diagnosis Summary Innate Immunity: • Neutropenia • Phagocytic Deficiencies • Complement
Infections in Immunocompromised ... Innate Immunity: • Neutropenia ... Medications • Chronic ... #Infections #differential ... #diagnosis #infectiousdiseases
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Basophilia - Differential ... allergic reaction or asthma ... Disorders: • Chronic ... ’s Disease • Asthma ... : • helminth infections
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... Headaches, bone pain, fever ... or functional neutropenia ... Lymphadenopathy • HSM • Fevers ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Lymphadenopathy • Fevers ... weeks without infection ... Cytopenias: • Neutropenia ... #CLL #Chronic
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... ) B symptoms → fevers ... Complications: 1) Infection ... PRCA, autoimmune neutropenia ... #oncology #hematology
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
status • Chronic ... encounters due to NTM: Chronic ... Marrow - Anemia, neutropenia ... #differential # ... diagnosis #infectiousdiseases
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
Lung Infections ... in HIV - Differential ... Less common since cART ... Abdominal pain, chronic ... #diagnosis #infectiousdiseases
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Marrow Failure • Chronic ... Myelogenous Leukemia ... • Hairy Cell Leukemia ... Myeloproliferative Disease • Neutropenia ... blood count with differential
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... • Cough, fever ... patients who are immunocompromised ... • Isolated fever ... ) #Mycoses #InfectiousDiseases
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