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The Causes of Cirrhosis

#Diagnosis #Differential #Hepatology #Cirrhosis #Causes
The Causes of Cirrhosis ... #Diagnosis #Differential ... #Hepatology #Cirrhosis ... #Causes
Ascites Differential Diagnosis Table - Serum Ascites Albumin Gradient (SAAG)

SAAG ≥ 1.1:
 • Cirrhosis
 • Portal
Ascites Differential ... Diagnosis Table ... SAAG ≥ 1.1: • Cirrhosis ... • Nephrotic syndrome ... #SAAG #hepatology
Diagnosis of ascites according to the serum ascites albumin gradient (SAAG)
SAAG ≥ 1.1:
 - Ascitic protein
Diagnosis of ascites ... ascites albumin gradient ... protein ≤ 2.5 g/dL: Cirrhosis ... #hepatology #differential ... #diagnosis #algorithm
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
Diagnosis Portal ... ) estimated by gradient ... Clues to non-cirrhotic ... #Diagnosis #causes ... #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Function Tests (LFTs ... ) - Differential ... Diagnosis Framework ... • NAFLD • Cirrhosis ... Diagnosis #hepatology
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
disease (Budd-Chiari syndrome ... 14 percent) #Diagnosis ... #Differential # ... Hepatology #Cirrhosis ... #Causes
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Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Diagnosis Algorithm ... Infiltrative • Cirrhosis ... • Others #LFTs ... #Hepatology #LiverEnzymes ... #Causes
Hepatopulmonary Syndrome (HPS) 

HPS-differential diagnosis:
1. Pulmonary vasculature
2. Diseases of the lung parenchyma
3. Pleura and diaphragm

HPS-diagnosis:
1. Patients
Hepatopulmonary Syndrome ... (HPS) HPS-differential ... Alveolar-arterial oxygen gradient ... Hepatopulmonary #Syndrome ... #HPS #hepatology
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
Ascites - Differential ... Diagnosis Chronic ... liver disease (cirrhosis ... Fitz-Hugh-Curtis syndrome ... #Diagnosis #hepatology
Causes of Portal Hypertension According to Site of Vascular Obstruction
1) Prehepatic pre-sinusoidal: Portal vein thrombosis due
Causes of Portal ... post-sinusoidal: Budd-Chiari syndrome ... portalhypertension #phtn #differential ... #diagnosis #causes ... #hepatology