7 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Sporadic, late-onset ... Ig deposits: Ig deposition ... Differential #Diagnosis #hematology
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
disease states Pathophysiology ... characterized by sudden onset ... Monosodium urate deposition ... • Nocturnal onset ... Gout #Comparison #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... SLE+++, Adult-onset ... treatment #summary #rheumatology
Gout - Diagnosis and Management Summary

3 Conditions for Gout to Manifest:
1. Hyperuricemia
2. Monosodium urate deposition in
Monosodium urate deposition ... • Nocturnal onset ... management #treatment #rheumatology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD)

Pathophysiology:
Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Pyrophosphate Deposition ... Disease (CPPD) Pathophysiology ... characterized by sudden onset ... Pyrophosphate #Deposition ... #Disease #Rheumatology
Scleroderma Renal Crisis (SRC)

Clinical Presentation of Scleroderma Renal Crisis:
1) Acute kidney injury
2) Abrupt onset of hypertension
3)
injury 2) Abrupt onset ... anemia (MAHA) Pathophysiology ... Renal #Crisis #rheumatology
Metabolic Pathways of Toxic Alcohols 

Panel A shows the metabolic pathways of toxic alcohols. Alcohol dehydrogenase
and delays the onset ... #Pathophysiology ... OsmolalGap #AnionGap #Timeline