1513 results
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... bile ducts causes cholestasis ... but elevated as disease ... Differential Diagnosis ... , IgG4 related disease
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary ... Cholangitis #pathophysiology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... of Intrahepatic cholestasis ... - Pruritis - Cholestasis ... granulamatous disease ... #Differential #Diagnosis
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
• Hereditary Cholestatic ... of intrahepatic cholestasis ... ) Intrahepatic cholestasis ... or intrahepatic cholestasis ... Classification #diagnosis
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Hepatocellular and Cholestatic ... Hepatocellular or Cholestatic ... R ≤ 2 = Cholestatic ... Hepatocellular #Cholestatic ... Transaminitis #diagnosis
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
- Differential Diagnosis ... Syndrome, Celiac Disease ... Thrombus, Vasospasm Cholestatic ... Hepatitis, TB Cholestatic ... #Differential #Diagnosis
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Biliary Cirrhosis - Pathophysiology ... female-predominant disease ... of autoimmune disease ... relative with PBC Pathophysiology ... biliary fibrosis - Cholestasis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential Diagnosis ... poisoning, ETOH Cholestatic ... epithelia: - Cholestasis ... ALT: typical of cholestatic ... #differential #diagnosis
Unintentional Weight Loss - Differential Diagnosis Framework

Malnutrition:
 • Limited access to food
 • Anorexia
 • Disorders
- Differential Diagnosis ... • Small bowel disease ... insufficiency • Cholestatic ... liver disease ... #Differential #Diagnosis
Lysosomal Storage Disorders

Mucolipidoses
 • I-Cell Disease

Mucopolysaccharidoses
 • Hurler
 • Hunter

Sphingolipidoses
 • Tay Sachs
 • Fabry
 •
Mucolipidoses • I-Cell Disease ... Storage #Disorders #Diseases ... #pathophysiology ... #diagnosis #differential