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Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis Clinical ... Highly variable clinical ... injury, though cholestatic ... reported (eg AIH-PBC ... mild laboratory, clinical
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis #pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... pathophysiology #pbc ... #psc #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
poisoning, ETOH Cholestatic ... stone, Malignancy, PBC ... elevation Labs in Cholestatic ... epithelia: - Cholestasis ... ALT: typical of cholestatic
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
def, Wilson's, Cholestatic ... dz Cholestatic ... Ducts - PBC ... , PSC, Alcoholic ... Biliary stricture, PSC
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Thrombus, Vasospasm Cholestatic ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... Hepatitis, TB Cholestatic
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Biliary Cirrhosis (PBC ... ) - Summary PBC ... bile ducts causes cholestasis ... , Intrahepatic cholestasis ... , Drug-induced cholestasis
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
of Intrahepatic cholestasis ... - Pruritis - Cholestasis ... biliary Cholangitis (PBC ... Infiltrative diseases - PSC
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
• Hereditary Cholestatic ... familial intrahepatic cholestasis ... of intrahepatic cholestasis ... ) Intrahepatic cholestasis ... or intrahepatic cholestasis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
RNA • R < 2: Cholestasis ... Obstruction: Cholestasis ... epithelia - Cholestasis ... ALT: typical of cholestatic ... • LDH: Heart, RBC
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Hepatocellular and Cholestatic ... Hepatocellular or Cholestatic ... R ≤ 2 = Cholestatic ... Hepatocellular #Cholestatic
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