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diagnosis rheumatology differential ana anca antibody antineutrophil antinuclear classification diseases nephrology pulmonary renal sle syndrome systemic vasculitides
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... erythematosus ... ANCA-Associated Vasculitis ... Renal-limited vasculitis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
ANCA-associated vasculitis ... • Mesenteric vasculitis ... titers > 1:80 • CBC ... 1, SCL-70, RNP antibodies ... anticardiolipin antibodies
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
(Eosinophilic granulomatosis ... polyangiitis, Granulomatosis ... Complex: Systemic lupus ... erythematosus, ... Investigations • Labs: CBC
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
(Granulomatous ... such as systemic lupus ... erythematosus, ... Lab Tests: • CBC ... C-ANCA) pattern: antibodies
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