19 results
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Nonalcoholic fatty liver ... (Budd-Chiari syndrome ... #Differential # ... Hepatology #Cirrhosis ... #Causes
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Causes of Fatigue ... Renal Failure • Liver ... Neoplastic / Hematologic ... • Anemia • ... #Fatigue #Differential
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
thrombocytopenia, hepatic encephalopathy ... Clues to non-cirrhotic ... /acute hepatitis ... #Diagnosis #causes ... #hepatology
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Non-Malignant • Fatty Liver ... Hemochromatosis • Wilson's Disease ... • Budd-Chiari Syndrome ... Primary Biliary Cirrhosis ... #Causes #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Cholestatic disease ... • Alcoholic hepatitis ... • Others #LFTs ... #Causes
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... hypoglycemia, encephalopathy ... infiltration) Differential ... Hepatitis, Preeclampsia ... #obstetrics #obgyn
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
discoloration) • Liver ... • Nephrotic syndrome ... #Differential # ... Diagnosis #Algorithm ... #causes
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
INR > 1.5 • Encephalopathy ... : < 1 • Cirrhosis ... • Gilbert's syndrome ... #chemistry #diagnosis ... #differential #
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... intralobular bile ducts causes ... • Pruritus • Fatigue ... bile ducts Differential ... Viral hepatitis,
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
Causes of Ascites ... Liver disease ... - Cirrhosis ... - Alcoholic hepatitis ... #diagnosis #differential