27 results
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Primary Routes of Clearance ... 100% Hepatic, 0% Renal ... 75% Hepatic, 25% Renal ... #DOAC #NOAC #Metabolism ... #Pharmacology #Clearance
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
DOAC: Cheat Sheet ... Dosing Renal ... Dosing: Apixaban ... (25% renal clearance ... @Bloodman #DOAC
Reduced DOAC Dosing for Atrial Fibrillation 

#DOAC #Reduced #Dosing #Reduction #Dose #Anticoagulation #Pharmacology #AFib #Renal #CKD
Reduced DOAC Dosing ... Fibrillation #DOAC ... #Reduced #Dosing ... Pharmacology #AFib #Renal
DOAC Cheat Sheet
 • Apixaban, Dabigatran, Edoxaban, Rivaroxaban
 • Renal Dosing
 • Common Drug interactions
 •
DOAC Cheat Sheet ... Rivaroxaban • Renal ... Dosing • Common ... DeLoughery @Bloodman #DOAC ... anticoagulation #CheatSheet #dosing
Warfarin to DOAC and DOAC to Warfarin Transitions 

Here are a couple of charts to help
Warfarin to DOAC ... and DOAC to Warfarin ... from warfarin to DOACs ... for easier dosing ... patients with good renal
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Management of DOACs ... anticoagulants (DOACs ... recent creatinine clearance ... (calculated using ... postoperative #DOAC
Adult Vancomycin Guidelines
The information below provides general dosing guidelines for vancomycin. A maintenance regimen of 15-20
provides general dosing ... current creatinine clearance ... is the accepted dosing ... AUC: MIC ratio.1 Dosing ... in renal impairment
Renal Replacement Therapy (RRT) - ICU One Pager Summary
Indications (AIEOU):
 • A: Acidosis (usually severe metabolic)
Renal Replacement ... CRRT (Continuous renal ... Provides diffusive ... clearance by running ... MD @nickmmark #Renal
Heparin - Unfractionated Heparin (UFH) vs Low-Molecular-Weight Heparin (LMWH)
UFH:
 • Advantages: 
    -
Rapid onset and clearance ... monitored - Ok in renal ... contraindicated in renal ... Unknown Optimal dosing
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
Decr IgA serum clearance ... Intussusception - Renal ... nephritic syndrome, renal ... HenochScholeinPurpura #Pathophysiology