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Coarctation of Aorta (CoA) & Interrupted Aortic Arch (IAA) • Prevalence • Anatomy of CoA •
Coarctation of Aorta (CoA ... • Anatomy of CoA ... Associated Lesions with CoA ... Management & Outcome of CoA ... Coarctation #Aorta #CoA
Atorvastatin. HMG-CoA reductase inhibitor (statin) for dyslipidemia and MI/stroke prevention. 2nd most prescribed drug in the
HMG-CoA reductase
Mechanism of Action of Bile Acid Sequestrants Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Pool → ↑ HMG-CoA
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
hydroxymethylglutaryl (HMG)-CoA
Medications Contributing to Dysgeusia Antimicrobial medicines Macrolides, fluoroquinolones, ampicillin, metronidazole, tetracycline, trimethoprim-sulfamethoxazole, amphotericin B, terbinafine and other antimycotic
procainamide HMG-CoA
Crystalloid pH, Contents and Costs Compared Plasma pH 7.4 Normal Saline pH 5.5* Ringer’s Lactate pH 6.5 Plasmalyte A pH 6.5 Coca-cola pH
Plasmalyte A pH 6.5 Coca-cola
Tumor markers in clinical practice Colorectal - CEA Hepatocellular - AFP Pancreatic - CA 19-9 Ovarian - CA 125 Breast -
Colorectal - CEA ... Pancreatic - CA ... 19-9 Ovarian - CA ... 125 Breast - CA
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
Blockers: • MOA ... Blockers: • MOA ... Blockers: • MOA ... receptors, and Ca ... : Block slow Ca+
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathway Activation (C3a ... and C5a) -> Anaphylatoxins
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
Pyruvate to Acetyl-CoA
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